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The high plasma levels of SAM that occur after a protein-rich meal inhibit the enzyme methylenetetrahydrofolate reductase (MTHFR), activate CBS, and cause homocysteine to be converted to cysteine

Adverse Effects All alpha agonists may cause sedation, somnolence and fatigue which may decrease over time

## **Other relevant codes** - **J7318**: Hyaluronan or derivative, durolane, for intra-articular injection, 1 mg - **J7320**: Hyaluronan or derivative, GenVisc 850, for intra-articular injection, 1 mg - **J7321**: Hyaluronan or derivative, hyalgan, supartz or visco-3, for intra-articular injection, per dose ### **References** Centers for Medicare & Medicaid Services (2024)

Some common symptoms of vitamin B12 deficiency include Vitamin B12 is essential for the production of red blood cells, and a deficiency can lead to anemia, which can cause fatigue and weakness