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doi: 10.1210/jc.2014-4024 90 Phase 1b/2a study to evaluate safety and efficacy of setmelanotide in obese patients

In the event of vitamin B12 deficiency, digestive disorders are common (nausea, diarrhoea, constipation)

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Effective natural remedies include increased hydration, magnesium and potassium supplementation, moist heat therapy, stretching and yoga, massage therapy, acupuncture, and stress-reduction practices like progressive muscle relaxation and diaphragmatic breathing