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by the researchers own account, results were mixed. A study of 29 adults published in 2005 suggested Protandim reduced measures of oxidative stress after a month, but lacked a placebo group

The findings raise concern about optic nerve vulnerability Although the report was not designed to demonstrate how the drugs may be associated with the damage, the authors suggested the optic nerve may be particularly sensitive to changes in blood flow or pressure related to GLP-1 drugs

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We further validated our findings in a different mouse model involving lipid peroxidation: doxorubicin induced liver damage (Supplementary Fig