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There are several potential sources of ROS/RNS in skeletal muscle but also other organs can participate in their production during exercise

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Interestingly, avoidance learning-an anxiety response-appears to depend on pkc activity as well, as it can be blocked by immediate polymixin B, a pkc and calcium/calmodulin-dependent kinase II inhibitor, applied to rat amygdala (Walker and Gold, 1994)

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