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Esmaeilzadeh et al., 2020)

Zn deficiency inhibits the dendritic differentiation of various cells, such as Purkinje and stellate cells, in the cerebellar cortex of 21-day-old rats and hinders the differentiation of human-induced pluripotent stem cells by modifying the Zn transporter gene expression (199201)

Environmental factors also play a role

Numerous research studies showed that fipronil sulfone was the cause of FPN-related neurotoxicity 9,11,50 , which is a mainly prevalent FPN metabolite in the livers of rodents and humans 27