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Mechanism mapping (Nature Communications, 2025) Identified the disordered p53 transactivation domain as the binding target, adding structural detail to the mechanism

We also consider the effect of these molecules on other obesity-related complications [glycaemia in people with T2D and on liver fat content in people with MASLD/metabolic dysfunction-associated steatohepatitis (MASH, previously known as non-alcoholic steatohepatitis)] and we discuss the potential clinical implications and challenges that the new era in obesity pharmacotherapy will bring

(An HHS spokesperson did not respond to a request for comment.) Just as Americans appetite for experimental drugs reaches new heights, the FDAs capacities to ensure the safety of Americas medicines seem to be diminishing.