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For genotoxic and carcinogenic compounds or compounds for which data presents high uncertainty on their effects and no intake can be defined as safe, the Margin of Exposure (MoE) approach is used, as suggested by EFSA (Barlow et al

doi: 10.1016/j.amjmed.2025.01.021

Abbreviations AG1478 4-(-3-chloroanilino)-6,7-dimethoxyquinozoline TPN Total parenteral nutrition IBD inflammatory bowel disease ERK Extracellular signal-regulated kinase MAPK Mitogen-activated protein kinase EGF epidermal growth factor EGFR EGF receptor PI3K Phosphatidylinositol 3-kinase TER transepithelial electrical resistance ZO-1, ZO-2 & ZO-3 zona occludens-1, -2 & -3 GSH glutathione REFERENCES 1.Lacey JM, Wilmore DW

Some protocols combine approaches, using local injection near primary wounds with periodic systemic dosing for comprehensive support