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PLoS One 6: e27598

The present study aimed at completing the data of the comprehensive experiment (12) and particularly to fill the knowledge gap regarding the direct influence of dietary L-carnitine supplementation on cellular level of leukocytes and on corresponding leukocyte-derived variables in the blood during a standardized immune challenge

Even though the specific roles that NKCC2 in these organs may have in glucose homeostasis remain unexplored, the potential relevance of extrarenal NKCC2 is underlined by the following: i ) the gluconeogenic capacity (Watford, 2005) of the small intestine supplies circulating glucose (Penhoat et al., 2014) and prevents obesity-related hepatic steatosis (Vily-Petit et al., 2020), ii ) the hypothalamus plays a central role in endocrine integration of fuel homeostasis, control of water/energy intake and feeding behavior (Schwartz et al., 2000

The mechanism of action is identical because the active ingredient is identical