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Differential expression patterns of matrix metalloproteinases and their inhibitors during development of osteoarthritis in a transgenic mouse model

In parallel, efforts are underway to identify early biomarkers, including those based on cerebrospinal fluid (CSF), peripheral blood, imaging modalities, and multi-omic signatures, to enable earlier intervention, before extensive neuronal loss has occurred

Metabolomic analysis was conducted for the liver tissue and serum samples and transcriptome of the liver tissue was also analyzed via RNA-seq

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