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As a follow-up to Lehninger's work several years later, Nishikimi and co-workers observed that the gene that codes for gulonolactone oxidase is actually present in humans, but is not active due to the accumulation of several mutations that turned it into a non-functional pseudogene (Nishikimi & Yagi 1991)

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Researchers found that TP can deplete GSH in liver cells and increase ROS, which induces oxidative stress (Figure 3) (Xu et al., 2019

Dietary Sources You can support natural glutathione production through nutrition: Sulphur-rich foods: Garlic, onions, and cruciferous vegetables (broccoli, kale, cabbage) boost cysteine levels, a key glutathione component