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Furthermore, as diarrhea and constipation are among the most frequently reported gastrointestinal AEs stemming from altered intestinal motility, their management should be expanded to include dietary fiber adjustments and targeted fluid repletion

However, some Middle Eastern countries and parts of Southeast Asia have stricter controlled substance regulations that may apply to certain peptide medications

When HS is damaged, the adhesion of leukocytes and platelets increases, which may lead to thrombosis and inflammation in arterioles, affect the blood supply to the kidneys, and impair GFR