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That percentage is even higher among women ages 50 to 64, where 20% of that population has taken a GLP-1 agonist drug

The extensive clinical trial programme for tirzepatide, including the SURPASS and SURMOUNT studies, did not identify cortisol dysregulation as an adverse effect or safety concern

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Similarly, increased CAT activity was reported in the livers of adult as well as pediatric MASH patients as compared to age-matched controls (Baker et al