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These medications work by mimicking GLP-1s multiple mechanisms: they slow gastric emptying (keeping you full longer), suppress glucagon release from the pancreas (reducing glucose production), stimulate insulin secretion when blood sugar is elevated, and most importantly for weight loss, directly activate satiety centers in the brains hypothalamus

A slower metabolic rate generates less internal warmth, which some patients perceive as increased cold sensitivity or chilliness

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Unlike nausea and vomiting, which are typically more transient, constipation (for those who experience it) appears to be a longer-lasting side effect of Ozempic