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Conditions affecting the small intestine, colon, or other digestive organs, such as indigestion, irritable bowel syndrome(IBS), Intestinal gas, or inflammatory bowel disease (IBD), can manifest as persistent pain

Poor circulation can also contribute to the development of more severe conditions, such as peripheral artery disease and chronic venous insufficiency

TNXB deficiency [51], and the recently defined clEDS type 2 caused by biallelic variants in AEBP1 [52]

By reducing the moisture content, flue curing also facilitates the preservation of the leaves, allowing them to be stored for longer periods without compromising their quality