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J Biol Chem (2009) 284:26591602.10.1074/jbc.M109.022491 63 Crowley-WeberCLDvorakovaKCrowleyCBernsteinHBernsteinCGarewalHet alNicotine increases oxidative stress, activates NF-kappa B and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis