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Our analytic sample was restricted to individuals with White British ancestry because APOE 4 allele frequencies vary between different populations 26 and the polygenic risk score for Alzheimer disease was based upon GWAS results from White participants

This trend is especially strong in North America, where strict tobacco laws amplify demand for alternatives

This complexity explains why the fragrance commands such devotion and why high-quality dupes must carefully replicate not just individual notes but their intricate relationships

In the first cigar, the first clump of ash drops off unceremoniously around half-an-inch, landing with an audible thud on my desk