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The second study demonstrated that exposure of human bronchial epithelial cells (BEAS-2B) over a 12-week period to total particulate matter produced from the THS2.2 heated tobacco product did not produce an increase in inflammatory mediators at a five-fold higher concentration when compared to total particulate matter from the 3R4F Kentucky reference cigarette (van der Toorn et al., 2018)

Discussion We examined and compared four kinds of self-report of cigarette consumption: Global retrospective estimates, day-by-day retrospective time-line follow-back without contemporaneous self-monitoring, TLFB during self-monitoring, and concurrent recording of cigarettes using an electronic diary to implement EMA methods