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Evidence-based interventions Although there are no FDA-approved medications specifically for cannabis dependence, psychotherapeutic interventions demonstrate benefit: Cognitive-Behavioral Therapy (CBT) CBT focuses on helping individuals: Identify and modify triggers and automatic thoughts related to use Build coping skills for cravings and high-risk situations Develop alternative behaviors that support sobriety goals CBT has extensive support in substance use treatment and is adaptable to diverse populations

While chronic tobacco use and vaping before or after TBI can exacerbate injury, animal studies report that nicotine itself has shown neuroprotective effects by regulating nicotine receptors (nAChRs) and enhancing dopamine signaling

This route is primarily an out-and-back experience, following a linear path along the American Tobacco Trail