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The FDA in June 2022 also announced that JUULs applications lacked sufficient evidence regarding the toxicological profile of the products to demonstrate that marketing of the products would be appropriate for the protection of the public health. The agency has also recently noted that scientific issues unique to its application warrant additional review and stated that the company still cannot legally market or sell its products

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Michle Rivasi points out an "alarming" trend: between 2002 and 2015, among women, the number of new annual cases of lung cancer increased by 72% and myocardial infarction by 50%