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The Food and Drug Administration recommends that companies developing smoking cessation treatments assess their impact on smoking for a minimum of four weeks, though a 26-week assessment is typically considered the preferred period for a study to reliably predict long-term abstinence from cigarettes

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In long-term or heavy use, reported issues include addiction (risk is 9% overall, but 17% for those who start use in adolescence, and up to 50% in those who are daily users), altered brain development, poor educational completion/outcomes, cognitive impairment (IQ levels impaired with frequent use during adolescence), diminished long-term life satisfaction, increased risk of psychotic disorders such as schizophrenia

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