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78 NNK is known to be a potent lung carcinogen, but also shows tumor induction activity in the nasal cavity, the pancreas, and the liver, whereas NNN has been shown to induce tumors along the respiratory tract and esophagus in various animal models

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Putrescine is then converted into N -methyl putrescine via methylation by SAM catalyzed by putrescine N -methyltransferase (PMT)

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