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Strong recommendation, high certainty Recommendation 11 For people who have abstained from smoking after a standard course of varenicline in combination with behavioural support, clinicians may consider a further course of varenicline to reduce relapse

It is worth noting that the use of the word cause in this last sentence was made possible by the invention of meta-analysis in statistics and epidemiology that the scientific pursuit of the carcinogenic effects of cigarette smoking spurred

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2008;33:25052516 [DOI] [PMC free article] [PubMed] [Google Scholar] 25.Hindocha C, Freeman TP, Schafer G, et al