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As might be expected, drop-out is a significant problem in this model

Once a person gets addicted to smoking, they would want to smoke every time they get stressed or angry

Reduced efficacy of tamoxifen has been reported with concomitant usage of some SSRI antidepressants in some studies

Despite this, research finds that among smokers and ex-smokers in the UK [footnote 26] : only 6 in 10 think that NRT is less harmful than smoking cigarettes 4 in 10 incorrectly think nicotine in cigarettes causes most of the smoking-related cancer Given these misconceptions, advising smokers on the relative safety of nicotine containing products compared to smoked tobacco is an integral part of supporting them to quit