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[205] Side effects Withdrawal symptoms The CDC recognizes seven common nicotine withdrawal symptoms that people often face when stopping smoking: "cravings to smoke, feeling irritated, grouchy, or upset, feeling jumpy and restless, having a hard time concentrating, having trouble sleeping, feeling hungry or gaining weight, or feeling anxious, sad or depressed." [207] Studies have shown that the use of pharmacotherapies, such as varenicline [208] [209] can be useful in reducing withdrawal symptoms during the quitting process

As smoking is the most common route of entry for nicotine, it will be discussed it in more detail below

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In fact, even drugs that are intended to be beneficial can, if misused, lead to the development of a substance use disorder