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Genetic factors significantly influence both smoking initiation and persistence, a schematic of these influences are presented in Figure 1, these include genes associated with differences in nicotine's metabolic capacity and nicotine effects on central nervous system neurotransmitter functionality, specifically the dose that modulate direct and indirect effects on nAChR, dopaminergic and opioidergic activity, respectively
Data on the prevalence of smoking among men ages 25 to 64 years and women ages 35 to 64 each display a flattening of this downward-trending curve from the early 1990s through the mid-2000s for both genders (see Figures 1-5 and 1-6)
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