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Clinical research from the CDC typically uses absorbed nicotine, which puts the figure closer to 1320 packs of cigarettes for an average user

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(The much larger prospective studies in the United States have also found no material change in mortality due to lung cancer in non-smokers between the 1960s and the 1980s.11 In smokers, the reductions in cause specific mortality, when they occurred, were smaller than in non-smokers (cerebrovascular disease was approximately constant, while ischaemic and other cardiovascular disease, taken together, decreased by only about a quarter)

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