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Study Limitations and Public Health Implications This study provides the first evidence connecting HTPs and cigarette exposure to elevated circulating LPS and zonulin in both children and adults, implying intestinal barrier dysfunction and cardiovascular risk

In some cases, infected individuals may not show any symptoms, yet may transmit the infection

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This intervention reduced senescence-associated -galactosidase-positive (SA--Gal + ) cells, reversed lung aging, diminished neutrophil infiltration in bronchoalveolar lavage fluid, and ultimately attenuated smoke-induced alveolar enlargement, highlighting its potential value in early COPD intervention (157)