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This review summarizes recent insights into small-airway physiology, key pathophysiological and molecular mechanisms, and current pharmacological strategies, and emphasizes the clinical principle of early detection, early diagnosis, early intervention for managing COPD-related small-airway disease

However, approximately 30.8 million adults currently smoke, and smokers comprise a significant proportion of surgical patients

To explore which environmental factors had the biggest role, researchers measured the production of cytokineskey messenger molecules that mediate inflammationin the blood of 1,000 healthy people after exposing the samples to either bacteria, fungi, antibodies or other agents known to elicit an immune response

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