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Smoking prevalence among youth declined faster after ENDS became widely available, 11 14 suggesting ENDS may have diverted nicotine-seeking youth away from cigarette smoking

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exposure to nicotine during adolescence can cause addiction and can harm the developing adolescent brain. Nicotine harms parts of the brain that control attention, learning, mood, and impulse control. Nicotine also changes the way synapses connections between brain cells are formed