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Cadmium itself is classified as a human carcinogen, and smokers have about twice as much of it in their bodies as do nonsmokers

Illustration by MacKenzie Olsberg Blog last updated: October 24, 2025

These data illustrate a specific challenge in studying the potential effects and harms of nicotine as much of the research into the potential harms of nicotine comes from studies in cells and animals where the doses used are often very high, leading to results that are controversial and difficult to extrapolate to humans

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